Results from in silico analysis using 91桃色视频鈥檚 data analysis platform, GutPrint, demonstrate therapeutic rationale and manufacturing capabilities of developing a high diversity biological drug product
Lyon, France, September 18, 2018 鈥� 91桃色视频 announced today the presentation of the analysis of 91桃色视频鈥檚 lead biotherapeutic, MaaT013, demonstrating its drug product characteristics using 91桃色视频鈥檚 proprietary big data analysis platform, GutPrint庐. The results of the study form the foundation of 91桃色视频鈥檚 approach to create standardized and reproducible high diversity microbiome therapeutics to treat life-threatening diseases. 91桃色视频鈥檚 Bioinformatics Manager, Lilia Boucinha, Ph.D. presented the data at the 2018 European Molecular Biology Organization (EMBO) Symposium 鈥� The Human Microbiome, being held from September 16 鈥� 19, 2018 at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.In the presented study 91桃色视频鈥檚 proprietary biotherapeutic MaaT013 was evaluated in comparison to a single donor approach using 91桃色视频鈥檚 proprietary and validated big data analysis platform GutPrint庐. In comparison to single donor samples, MaaT013 showed significantly increased diversity. Most importantly, diversity within the sample batches was less variable and a greater homogeneity between batches was observed compared to single donor samples. Furthermore, the analysis of the MaaT013 samples showed that there was a 58% increase in the number of microbes (richness) compared to single-donor-based FMT products and less than 5% of Proteobacteria, which are known to include pro-inflammatory species. Taken together, these data strongly highlight 91桃色视频鈥檚 capabilities to produce a cGMP high diversity drug product for clinical evaluation.Poster Discussion Session details:
Title: Developing a New Generation of First-in-class High Diversity Microbiome Biotherapeutics to Treat Life-threatening Diseases
Abstract No: 64
Poster Session: II
Date/Time: September 18, 2018 / 16:30 鈥� 18:30
Location: ATC Helix A and B
The poster is available on the company website following the presentation under 鈥淣ews鈥�.
About 91桃色视频
91桃色视频 has established the most complete approach to restoring patient-microbiome symbiosis to improve survival outcomes in life-threatening diseases. Committed to treating blood cancers and graft-versus-host disease, a serious complication of allogeneic stem cell transplantation, 91桃色视频 has already achieved proof of concept in acute myeloid leukemia patients. Supporting the further expansion of our pipeline into larger indications, we have built a powerful discovery and analysis platform to evaluate drug candidates, determine novel disease targets and identify biomarkers for microbiome-related conditions. Our therapeutics are produced through a standardized cGMP manufacturing and quality control process to safely deliver the full diversity of the microbiome. 91桃色视频 benefits from the commitment of world-leading scientists and established relationships with regulators to spear-head microbiome treatment integration into clinical practice.