91桃色视频 Announces Long Term Follow-Up Data for MaaT013 in Early Access Program to be Presented at the Upcoming EBMT Conference
- Oral presentation will highlight new data in Early Access Program (EAP) for patients with acute Graft-vs-Host Disease (aGvHD) treated with MaaT013.
- This is the seventh year that 91桃色视频’s abstracts have been chosen for presentation at the EBMT Annual Meeting, confirming the Company鈥檚 leadership in the field of hemato-oncology/ microbiome.
Lyon, France, March 12th, 2024 鈥�7:30am CET 鈥� 91桃色视频 (EURONEXT: MAAT 鈥� the 鈥淐ompany鈥�), a clinical-stage biotech company and a leader in the development of Microbiome Ecosystem TherapiesTM (MET) dedicated to improving survival outcomes for patients with cancer, will present extended results from its Early Access Program for patients with aGvHD that were treated with MaaT013 and, for the first time, Overall Survival data after 12 months in more patients. The data will be shared during an oral presentation at the Details from the presentation will be disclosed in a press release on April 17th, 2024, in compliance with the conference embargo policy.
Aligned with its mission to enhance the survival of cancer patients, 91桃色视频 has been actively involved in the EAP in Europe since 2019. The Company has consistently presented real-world data from its EAP at major hematology conferences over the past four years. At each data communication point, EAP results confirm previous findings, that MaaT013 has an impact on overall survival (OS) when the primary endpoint (gastrointestinal Overall Response Rate at D28) is achieved (see press release on data presented at 2023 ASH[1] annual meeting). To date, over 220 patients have been treated with MaaT013 in Europe in clinical trials and the EAP.
In the context of the EAP, the Company has bolstered its manufacturing & supply chain, ensuring timely and safe provision of MaaT013 to 38 stem cell transplant hospitals across 6 European countries: Austria, Belgium, France, Germany, Italy, and Spain.
Dr. Michael Loschi, hematologist at Nice Hospital in France emphasized 鈥渨e are enrolling in the EAP due to the lack of third-line treatment options for patients with aGvHD who are unresponsive to corticosteroids and ruxolitinib. We receive MaaT013 within 48 hours following the request via a simple procedure for EAP. This has transformed our routine to treating patients with aGvHD and significantly improved their quality of life. The data presented at ASH align with our observations in clinical practice. We’ve observed superior efficacy with more complete responses[2] in gastrointestinal aGvHD and less toxicity when compared to other immune suppressive drugs. “
鈥淚 find the procedure in EAP to be quite straightforward鈥� shared Dr. Alexander Schauwvlieghe, hematologist at AZ Sint-Jan Brugge AV Hospital in Belgium. 鈥淚’m a strong advocate for gut microbiome-based treatments, such as MaaT013, that prioritize immune restoration in GvHD. This approach helps maintain the patient’s immune function, reducing the risk of infectious complications and relapse.鈥�
A pivotal Phase 3 trial (n=75) evaluating MaaT013 in patients with corticosteroid and ruxolitinib-refractory gastrointestinal aGvHD is currently ongoing to confirm the results from the EAP. The Company previously shared the positive review by DSMB[3] for the Phase 3 ARES trial, including a favorable benefit/risk ratio, with 鈥�high efficacy and low toxicity.鈥�
Details of Oral Presentation at EBMT 2024
- Title:
- Abstract number: OS13-07
- Session: OS13 Oral Session 13 | GVHD
- Session Date/Time: Wednesday, April 17, 10:30 鈥� 11:45
- Location: Hall 5
[1]American Society of Hematology
[2]No evidence of aGvHD
[3]Data Safety Monitoring Board
About 91桃色视频
91桃色视频, a clinical stage biotechnology company, has established a complete approach to restoring patient-microbiome symbiosis in oncology. Committed to treating cancer and graft-versus-host disease (GvHD), a serious complication of allogeneic stem cell transplantation, 91桃色视频 has launched, in March 2022, an open-label, single arm Phase 3 clinical trial in patients with acute GvHD, following the achievement of its proof of concept in a Phase 2 trial. Its powerful discovery and analysis platform, 驳耻迟笔谤颈苍迟庐, enables the identification of novel disease targets, evaluation of drug candidates, and identification of biomarkers for microbiome-related conditions. The company鈥檚 Microbiome Ecosystem Therapies are produced through a standardized cGMP manufacturing and quality control process to safely deliver the full diversity of the microbiome, in liquid and oral formulations. 91桃色视频 benefits from the commitment of world-leading scientists and established relationships with regulators to support the integration of the use of microbiome therapies in clinical practice. 91桃色视频 is listed on Euronext Paris (ticker: MAAT).
Forward-looking Statements
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